DNA helicases catalyze the disruption of the hydrogen bonds that hold the two strands of double‐stranded DNA together. This energy‐requiring unwinding reaction results in the formation of the single‐stranded DNA required as a template or reaction intermediate in DNA replication, repair and recombination. A combination of biochemical and genetic studies have been used to probe and define the roles of the multiple DNA helicases found in E. coli. This work and similar efforts in eukaryotic cells, although far from complete, have (...) established that DNA helicases are essential components of the machinery that interacts with the DNA molecule. (shrink)

1 The Zero-Force Evolutionary Law 2 Randomness, Hierarchy, and Constraint 3 Diversity 4 Complexity 5 Evidence, Predictions, and Tests 6 Philosophical Foundations 7 Implications.

Our ability to locate moral responsibility is often thought to be a necessary condition for conducting morally permissible medical practice, engaging in a just war, and other high-stakes endeavors. Yet, with increasing reliance upon artificially intelligent systems, we may be facing a wideningresponsibility gap, which, some argue, cannot be bridged by traditional concepts of responsibility. How then, if at all, can we make use of crucial emerging technologies? According to Colin Allen and Wendell Wallach, the advent of so-called ‘artificial moral (...) agents’ (AMAs) is inevitable. Still, this notion may seem to push back the problem, leaving those who have an interest in developing autonomous technology with a dilemma. We may need to scale-back our efforts at deploying AMAs (or at least maintain human oversight); otherwise, we must rapidly and drastically update our moral and legal norms in a way that ensures responsibility for potentially avoidable harms. This paper invokes contemporary accounts of responsibility in order to show how artificially intelligent systems might be held responsible. Although many theorists are concerned enough to develop artificial conceptions ofagencyor to exploit our present inability to regulate valuable innovations, the proposal here highlights the importance of—and outlines a plausible foundation for—a workable notion ofartificial moral responsibility. (shrink)

Gilles Deleuze was one of the most influential philosophers of the twentieth-century, and Smith is widely recognized to be one of his most penetrating interpreters, as well as an important philosophical voice in his own right. Combining his most important pieces over the last fifteen years along with two new essays, this book is Smith 's definitive treatise on Deleuze. The essays are divided into four sections, which cover Deleuze's use of the history of philosophy, an overview of his philosophical (...) system, an analysis of several Deleuzian concepts, as well as an assessment of his position within contemporary philosophy. (shrink)

In this study, Daniel W. Graham addresses two major problems in interpreting Aristotle. First, should we reconcile the apparent inconsistencies of the corpus by assuming an underlying unity of doctrine, or by positing a sequence of developing ideas? Secondly,what is the relation between the so-called logical works on the one hand and the physical-metaphysical treatises on the other? Although the problems appear to be unrelated, Graham finds that the key to the first lies in the second, and in doing (...) so provides the first major alternative to theunitarian approach since Jaeger's pioneering developmental study of 1923. (shrink)

The experience of ‘moral distress’ is an increasing focal point of contemporary medical and bioethics literature, yet it has received little attention in discussions intersecting with ethical theory. This is unfortunate, as it seems that the peculiar phenomenon may well help us to better understand a number of issues bearing both practical and theoretical significance. In this article, I provide a robust psychological profile of moral distress in order to shed a newfound light upon the longstanding problem of ‘dirty hands’. (...) I argue that moral distress offers evidence of the existence of dirty hands situations. By examining moral distress and its relationship to cases of dirty hands, it appears that few of us are completely immune to susceptibility to these sorts of troubling experiences. With this concern in mind, I provide various recommendations to help alleviate our morally distressing personal and professional lives. (shrink)

"The Invention of Modern Science proposes a fruitful way of going beyond the apparently irreconcilable positions, that science is either "objective" or "socially constructed." Instead, suggests Isabelle Stengers, one of the most important and influential philosophers of science in Europe, we might understand the tension between scientific objectivity and belief as a necessary part of science, central to the practices invented and reinvented by scientists."--pub. desc.

The _Physics_ is a foundational work of western philosophy, and the crucial one for understanding Aristotle's views on matter, form, essence, causation, movement, space, and time. This richly annotated, scrupulously accurate, and consistent translation makes it available to a contemporary English reader as no other does—in part because it fits together seamlessly with other closely associated works in the New Hackett Aristotle series, such as the _Metaphysics_, _De Anima_, and forthcoming _De Caelo_ and _On Coming to Be and Passing Away_. (...) Eventually the series will include all of Aristotle's works. Sequentially numbered endnotes provide the information most needed at each juncture, while a detailed Index of Terms indicates places where focused discussion of key notions occurs. An illuminating general Introduction describes the book that lies ahead, explaining what sort of work it is and what sorts of evidence it relies on. (shrink)

The conventional wisdom declares that evolution is not goal directed, that teleological considerations play no part in our understanding of evolutionary trends. Here I argue that, to the contrary, under a current view of teleology, field theory, most evolutionary trends would have to be considered goal directed to some degree. Further, this view is consistent with a modern scientific outlook, and more particularly with evolutionary theory today. Field theory argues that goal directedness is produced by higher-level fields that direct entities (...) contained within them to behave persistently and plastically, that is, returning them to a goal-directed trajectory following perturbations (persistence) and directing them to a goal-directed trajectory from a large range of alternative starting points (plasticity). The behavior of a bacterium climbing a chemical food gradient is persistent and plastic, with guidance provided by the external “food field,” the chemical gradient. Likewise, an evolutionary trend that is produced by natural selection is a lineage behaving persistently and plastically under the direction of its local ecology, an “ecological field.” Trends directed by selection-generated boundaries, thermodynamic gradients, and certain internal constraints, would also count as goal directed. In other words, most of the causes of evolutionary trends that have been proposed imply goal directedness. However, under field theory, not all trends are goal directed. Examples are discussed. Importantly, nothing in this view suggests that evolution is guided by intentionality, at least none at the level of animal intentionality. Finally, possible implications for our thinking about evolutionary directionality in the history of life are discussed. (shrink)

Robotic and artificially intelligent (AI) systems are becoming prevalent in our day-to-day lives. As human interaction is increasingly replaced by human–computer and human–robot interaction (HCI and HRI), we occasionally speak and act as though we are blaming or praising various technological devices. While such responses may arise naturally, they are still unusual. Indeed, for some authors, it is the programmers or users—and not the system itself—that we properly hold responsible in these cases. Furthermore, some argue that since directing blame or (...) praise at technology itself is unfitting, designing systems in ways that encourage such practices can only exacerbate the problem. On the other hand, there may be good moral reasons to continue engaging in our natural practices, even in cases involving AI systems or robots. In particular, daily interactions with technology may stand to impact the development of our moral practices in human-to-human interactions. In this paper, we put forward an empirically grounded argument in favor of some technologies being designed for social responsiveness. Although our usual practices will likely undergo adjustments in response to innovative technologies, some systems which we encounter can be designed to accommodate our natural moral responses. In short, fostering HCI and HRI that sustains and promotes our natural moral practices calls for a co-developmental process with some AI and robotic technologies. (shrink)

Deleuze argued that a fundamental mutation in the concept of time occurred in Kant. In antiquity, the concept of time was subordinated to the concept of movement: time was a ‘measure’ of movement. In Kant, this relation is inverted: time is no longer subordinated to movement but assumes an autonomy of its own: time becomes "the pure and empty form" of everything that moves and changes. What is essential in the theory of time is not the distinction between objective ‘clock (...) time’ (or physical time) and the subjective experience of ‘time consciousness,’ since both of them measure movements, whether the movement of extensive objects or intensive states. What is fundamental is rather the relation between time and movement, since time can only assume its own concept when it ceases to be subordinate to movement, whether that movement is objective or subjective. This article examines how Kant inverted the relation between time and movement, and how Deleuze’s own theory of time builds on Kant’s revolution and extends it further. (shrink)

What is the concept of sense developed by Deleuze in his 1969 Logic of Sense? This paper attempts to answer this question analysing the three dimensions of language that Deleuze isolates: the primary order of noises and intensities ; the secondary order of sense ; and the tertiary organisation of propositions. What renders language possible is that which separates sounds from bodies and organises them into propositions, freeing them for the expressive function. Deleuze argues that it is the dimension of (...) sense that brings about this genesis of language, and he analyses in detail the three syntheses that bring about the production of this surface of sense. Yet Deleuze also distinguishes between two types of non-sense: the nonsense of Lewis Carroll's portmanteau words, which remain ensconced in the dimension of sense, and the more profound nonsense of Antonin Artaud's psychotic scream-breaths, which penetrate the almost unbearable world of the primary order of noise and intensities. In the end, the focus of Logic of Sense is less the surface domain of sense than the primary depth of corporeal intensities. What Deleuze calls a ‘minor’ use of language is nothing other than an intensive use of language that constitutes a principle of metamorphosis. (shrink)

Renewed interest in the Presocratics of the last few decades has not ignored Heraclitus, and some new and fruitful lines of inquiry are now being pursued. This article on Heraclitus presents a unified Heraclitus who is a thoughtful critic of his predecessors, and keenly interested in the possibility of human understanding. This Heraclitus rejects the Milesian account of a single substance with systematic changes and transformations that guarantee the stability of the whole. He recognizes that his new views will be (...) difficult to understand, but provides hints and lessons to allow his hearer or reader to grasp his philosophical account. Parmenides of Elea, too, has not been ignored by the scholarly community—a number of new interpretations of Parmenides have appeared in the last decade. (shrink)

This chapter contains sections titled: Life as Will to Power Nietzsche contra “English Darwinism” Life as Self‐Overcoming The Case of Nietzsche The Law of Life Concluding Critical Remarks.

According to a popular family of theories, assertions and other communicative acts should be understood as attempts to change the context of a conversation. Contexts, on this view, are publicly shared bodies of information that evolve over the course of a conversation and that play a range of semantic and pragmatic roles. I argue that this view is mistaken: performing a communicative act requires aiming to change the mind of one’s addressee, but not necessarily the context. Although changing the context (...) may sometimes be among a speaker’s aims, this should be seen as an extra-communicative aim, rather than one that is necessary for the performance of a communicative act. Along the way, I also argue that contexts needn’t play a role in linking anaphora to their antecedents. On the view that I defend, theories that take publicly shared contexts to play an essential role in the nature of communicative acts or anaphoric dependence conflate an artifact introduced by idealized models of conversation with a feature of the phenomenon being modeled. (shrink)

Mathematical Logic: An Introduction is a textbook that uses mathematical tools to investigate mathematics itself. In particular, the concepts of proof and truth are examined. The book presents the fundamental topics in mathematical logic and presents clear and complete proofs throughout the text. Such proofs are used to develop the language of propositional logic and the language of first-order logic, including the notion of a formal deduction. The text also covers Tarski’s definition of truth and the computability concept. It also (...) provides coherent proofs of Godel’s completeness and incompleteness theorems. Moreover, the text was written with the student in mind and thus, it provides an accessible introduction to mathematical logic. In particular, the text explicitly shows the reader how to prove the basic theorems and presents detailed proofs throughout the book. Most undergraduate books on mathematical logic are written for a reader who is well-versed in logical notation and mathematical proof. This textbook is written to attract a wider audience, including students who are not yet experts in the art of mathematical proof. (shrink)

Given that \(L(\mathbb {R})\models {\text {ZF}}+ {\text {AD}}+{\text {DC}}\), we present conditions under which one can generically add new elements to \(L(\mathbb {R})\) and obtain a model of \({\text {ZF}}+ {\text {AD}}+{\text {DC}}\). This work is motivated by the desire to identify the smallest cardinal \(\kappa \) in \(L(\mathbb {R})\) for which one can generically add a new subset \(g\subseteq \kappa \) to \(L(\mathbb {R})\) such that \(L(\mathbb {R})(g)\models {\text {ZF}}+ {\text {AD}}+{\text {DC}}\).

Is life a purely physical process? What is human nature? Which of our traits is essential to us? In this volume, Daniel McShea and Alex Rosenberg – a biologist and a philosopher, respectively – join forces to create a new gateway to the philosophy of biology; making the major issues accessible and relevant to biologists and philosophers alike. Exploring concepts such as supervenience; the controversies about genocentrism and genetic determinism; and the debate about major transitions central to contemporary thinking (...) about macroevolution; the authors lay out the broad terms in which we should assess the impact of biology on human capacities, social institutions and ethical values. (shrink)

This paper was presented as the keynote address at the 2005 Philosophy Graduate Student Conference at the University of Memphis on “Limitations of Subjectivity.”.

It is an understatement to say we live in an exciting time considering the increasingly widespread applications of artificial intelligence (AI). This observation is brought to the fore by Sedlakova...

The “Treatise on Nomadology: The War Machine" is one of the most important and innovative chapters in Gilles Deleuze and Felix Guattari's book, A Thousand Plateaus. It is a highly original text in political philosophy whose implications have yet to be fully mined—or even partially mined, for that matter. This short text analyzes the "noumenal" status that Deleuze assigns to the nomadic war machine, and analyzes the fundamental role that the nomadology plays in Deleuze and Guattari's political philosophy.

The experience of ‘moral distress’ is an increasing focal point of contemporary medical and bioethics literature, yet it has received little attention in discussions intersecting with ethical theory. This is unfortunate, as it seems that the peculiar phenomenon may well help us to better understand a number of issues bearing both practical and theoretical significance. In this article, I provide a robust psychological profile of moral distress in order to shed a newfound light upon the longstanding problem of ‘dirty hands’. (...) I argue that moral distress offers evidence of the existence of dirty hands situations. By examining moral distress and its relationship to cases of dirty hands, it appears that few of us are completely immune to susceptibility to these sorts of troubling experiences. With this concern in mind, I provide various recommendations to help alleviate our morally distressing personal and professional lives. (shrink)

Moral distress in healthcare has been an increasingly prevalent topic of discussion. Most authors characterize it as a negative phenomenon, while few have considered its potentially positive value. In this essay, I argue that moral distress can reveal and affirm some of our most important concerns as moral agents. Indeed, the experience of it under some circumstances appears to be partly constitutive of an honorable character and can allow for crucial moral maturation. The potentially positive value, then, is twofold; moral (...) distress carries both aretaic and instrumental value. Granted, this position is not without its caveats, but by making these clear, I provide a novel framework for policy recommendations regarding when, if ever, we should work to reduce moral distress. (shrink)

Long recognized as a masterpiece of Nietzsche scholarship, _Nietzsche and the Vicious Circle_ is made available here for the first time in English. Taking a structuralist approach to the relation between Nietzsche's thought and his life, Klossowski emphasizes the centrality of the notion of Eternal Return for understanding Nietzsche's propensities for self-denial, self-reputation, and self-consumption. Nietzsche's ideas did not stem from personal pathology, according to Klossowski. Rather, he made a pathological use of his best ideas, anchoring them in his own (...) fluctuating bodily and mental conditions. Thus Nietzsche's belief that questions of truth and morality are at base questions of power and fitness resonates dynamically and intellectually with his alternating lucidity and delirium. (shrink)

Daniel Graham offers a clear, accurate new translation of the eighth book of Aristotle's Physics, accompanied by a careful philosophical commentary to guide the reader towards understanding of this key text in the history of Western thought. It is the culmination of Aristotle's theory of nature: he explains motion in the universe in terms of a single source and regulating principle, a first `unmoved mover'.

What makes it the case that an utterance constitutes an illocutionary act of a given kind? This is the central question of speech-act theory. Answers to it—i.e., theories of speech acts—have proliferated. Our main goal in this chapter is to clarify the logical space into which these different theories fit. -/- We begin, in Section 1, by dividing theories of speech acts into five families, each distinguished from the others by its account of the key ingredients in illocutionary acts. Are (...) speech acts fundamentally a matter of convention or intention? Or should we instead think of them in terms of the psychological states they express, in terms of the effects that it is their function to produce, or in terms of the norms that govern them? In Section 2, we take up the highly influential idea that speech acts can be understood in terms of their effects on a conversation’s context or “score”. Part of why this idea has been so useful is that it allows speech-act theorists from the five families to engage at a level of abstraction that elides their foundational disagreements. In Section 3, we investigate some of the motivations for the traditional distinction between propositional content and illocutionary force, and some of the ways in which this distinction has been undermined by recent work. In Section 4, we survey some of the ways in which speech-act theory has been applied to issues outside semantics and pragmatics, narrowly construed. (shrink)